Rimantadine HCl

A to Z Drug Facts

Rimantadine HCl

	Action
	Indications
	Contraindications
	Route/Dosage
	Interactions
	Lab Test Interferences
	Adverse Reactions
	Precautions
Patient Care Considerations
	Administration/Storage
	Assessment/Interventions
	Patient/Family Education

(rih-MAN-tuh-deen HIGH-droe-KLOR-ide)

Flumadine

Syrup: 50 mg/5 mL

Tablets: 100 mg

Class: infective, Antiviral

Action Inhibits viral replication cycle in various strains of influenza A virus.

Indications

Adults

Prophylaxis and treatment of infection caused by various strains of influenza A virus.

Children

Prophylaxis against influenza A virus.

Contraindications Hypersensitivity to drugs of adamantine class including rimantadine and amantadine.

Route/Dosage

Prophylaxis and Treatment

ADULTS: PO 100 mg bid.

ELDERLY Nursing Home Patients, Hepatic and Renal Impairment (Ccr < 10 mL/min): Reduce to 100 mg/day.

Prophylaxis

CHILDREN ³ 10 yr: PO 100 mg bid.

CHILDREN < 10 yr: PO 5 mg/kg/day (max, 150 mg/dose).

Interactions

Acetaminophen, Aspirin

Decreased peak serum concentration of rimantadine.

Cimetidine

Increased serum concentration caused by decreased clearance.

Lab Test Interferences None well documented.

Adverse Reactions

CNS: Insomnia; dizziness; headache; nervousness; asthenia; impaired concentration. EENT: Eye pain. GI: Nausea; vomiting; anorexia; dry mouth; abdominal pain.

Precautions

Pregnancy: Category C. Lactation: Undetermined. Do not administer to nursing mothers. Children: Safety and efficacy for prophylaxis not established in children < 1 yr. Elderly: CNS symptoms may occur more frequently. Seizures: Increased incidence of seizures in patients with seizure history and who receive amantadine.

PATIENT CARE CONSIDERATIONS

Administration/Storage

Administer orally only.
Store at room temperature.

Assessment/Interventions

Obtain patient history, including drug history and any known allergies.
Assess baseline renal and LFT results.
Notify health care provider if patient has seizure activity, severe or persistent diarrhea, dizziness, impaired concentration, asthenia, or dyspnea.

OVERDOSAGE: SIGNS & SYMPTOMS
	Agitation, cardiac arrhythmias, hallucinations, death

Patient/Family Education

Tell patient with history of seizures to discontinue drug and notify health care provider if seizure activity develops.
Instruct patient to report insomnia, dizziness, headache, nervousness, asthenia, impaired concentration, nausea, vomiting, anorexia, persistent diarrhea, dry mouth, abdominal pain, dyspnea, cough, palpitations, or syncope.
Caution patient to avoid driving or operating hazardous equipment if dizziness or confusion develops.
Advise patient to take drug several hours before going to bed if insomnia develops.

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